关键词: 生物安全管理, 实验动物中心, 多学科交叉, 管理体系, 实践范式

Abstract: The level of biosafety management at university laboratory animal centers is crucial to their high-quality development. Against the backdrop of multidisciplinary integration, establishing a practical and effective biosafety management system has become the foremost priority for all centers. Taking the Model Animal Research Center of Shandong University as a case study, this paper outlines a five-pronged biosafety management system encompassing training protocols, standardized operations, animal quality control, critical process oversight, and emergency response. After over three years of implementation, significant achievements have been realized: training assessment pass rates reached 97.0% with 92.6% participation; 304 quality control documents were established to ensure standardized end-to-end operations; animal infection rates decreased by 95.0% while microbial testing compliance reached 99.8%; material disinfection compliance and air cleanliness reached 96.5% and 98.0%, respectively; emergency response time shortened by 65.1%, with drill participation at 92.7%. This paper explores a multidisciplinary, center-specific biosafety management system that ensures high-quality development while providing a replicable model for domestic university animal centers facing similar management challenges.

Key words: biosafetymanagement, laboratory animal center;multidisciplinary integration;management system;practiceparadigm